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KMID : 0363219940320061131
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Korean Journal of Dermatology
1994 Volume.32 No. 6 p.1131 ~ p.1135
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A Case of Acquired Digital Fibrokeratoma-Immunohistochemical Stain with Anti-factor XIIIa Antibody-
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서호석
류병직/최지호/성경제/고재경
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Abstract
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In normal human dermis, factor XIIIa positive dermal dendrocytes are located in the papillary areas closely associated with blood vessels and the upper reticular dermis. These cells represent a specific type of bone marrow derived dermal cells,
distinct
from Langerhans cells having some features in common with monocyte/macrophage lineage and lineage ad with potential antigen presenting activity. Although the significance of these of these cells has not yet been fully established, it has been
suggested
that they play a major role in skin immune responses, in collagen synsthesis regulation, and in wound repair.
We report a case of acuqired fibrokeratoma which is studied by conventional histopathology and immunohistochemistry. Histopathologic findings of this case show fibrovascular proliferation and the increased presence of fibroblast like cells as a
common
feature of these benign tumors. Immunohistochemical staining with anti factor XIIIa antibody demonstrates increased numbers of positive dendritic cells in the upper dermis. This finding supports the fact that some fibroblast like cells in the
upper
dermis of acquired fibrokeratoma may be factor XIIIa positive dermal dendritic cells. (Kor J Dermatol 1994 ; 32(6) : 1131~1135)
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